Assay Detail
Functional
CHEMBL2169129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 harboring reverse transcriptase K101E mutant infected in human TZM-bl cells assessed as inhibition of viral replication after 2 days by luciferase reporter gene based luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.13 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165299 | — | — | 1 | 8.47 |
| CHEMBL2012795 | — | — | 1 | 8.47 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 8.24 |
| CHEMBL2012793 | — | — | 1 | 8.08 |
| CHEMBL1632241 | — | — | 1 | 7.96 |
| CHEMBL2165297 | — | — | 1 | 7.85 |
| CHEMBL2165294 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165299 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2012795 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL2012793 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL1632241 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2165297 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2165294 | — | EC50 | = | 14.0 | nM | 7.85 |