Assay Detail
Binding
CHEMBL2169296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B1 expressed in hamster V79 MZh cells using deoxycorticosterone substrate
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.72 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163638 | — | — | 1 | 8.85 |
| CHEMBL2163639 | — | — | 3 | 8.82 |
| CHEMBL2163640 | — | — | 1 | 8.47 |
| CHEMBL2163637 | — | — | 1 | 8.19 |
| CHEMBL2163651 | — | — | 1 | 7.89 |
| CHEMBL2163636 | — | — | 1 | 7.77 |
| CHEMBL2163641 | — | — | 1 | 7.72 |
| CHEMBL2163650 | — | — | 1 | 7.70 |
| CHEMBL2163644 | — | — | 1 | 7.57 |
| CHEMBL2163643 | — | — | 1 | 7.54 |
| CHEMBL2163642 | — | — | 1 | 7.40 |
| CHEMBL2163646 | — | — | 1 | 7.40 |
| CHEMBL2163649 | — | — | 1 | 7.30 |
| CHEMBL2163648 | — | — | 1 | 7.16 |
| CHEMBL2163645 | — | — | 1 | 6.96 |
| CHEMBL2163647 | — | — | 1 | 6.84 |
| CHEMBL2163652 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163638 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2163639 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2163639 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2163640 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2163637 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2163639 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL2163651 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2163636 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2163641 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2163650 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2163644 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2163643 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2163642 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2163646 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2163649 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2163648 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2163645 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2163647 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2163652 | — | IC50 | = | 438.0 | nM | 6.36 |