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Assay Detail

CHEMBL2173028

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathogenicity by Cell Titer-Glo assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Respiratory syncytial virus
Cell Type HEp-2
Confidence 1 — Organism
Curated By Autocuration

Target

Respiratory syncytial virus (CHEMBL612679)
Type ORGANISM
Organism Respiratory syncytial virus

Publication

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.
Moore BP, Chung DH, Matharu DS, Golden JE, Maddox C, Rasmussen L, Noah JW, Sosa MI, Ananthan S, Tower NA, White EL, Jia F, Prisinzano TE, Aubé J, Jonsson CB, Severson WE.
J Med Chem (2012) 55 : 8582 -8587
PubMed 23043370 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 5.13 5.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2171476 1 5.66
CHEMBL2171474 1 5.64
CHEMBL2171278 1 5.57
CHEMBL2171478 1 5.38
CHEMBL1495736 1 5.30
CHEMBL2171470 1 4.75
CHEMBL2171469 1 4.67
CHEMBL2171281 1 4.62
CHEMBL1643 RIBAVIRIN 4.0 1 4.55
CHEMBL2171473 1 -
CHEMBL2171472 1 -
CHEMBL2171471 1 -
CHEMBL2171477 1 -
CHEMBL2171479 1 -
CHEMBL2171468 1 -
CHEMBL2171467 1 -
CHEMBL2171475 1 -
CHEMBL2171480 1 -
CHEMBL2171280 1 -
CHEMBL1338351 1 -
CHEMBL2171279 1 -
CHEMBL2171481 1 -
CHEMBL2171277 1 -
CHEMBL2171482 1 -
CHEMBL2171483 1 -
CHEMBL2171466 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2171476 EC50 = 2200.0 nM 5.66
CHEMBL2171474 EC50 = 2300.0 nM 5.64
CHEMBL2171278 EC50 = 2700.0 nM 5.57
CHEMBL2171478 EC50 = 4200.0 nM 5.38
CHEMBL1495736 EC50 = 5000.0 nM 5.30
CHEMBL2171470 EC50 = 17600.0 nM 4.75
CHEMBL2171469 EC50 = 21200.0 nM 4.67
CHEMBL2171281 EC50 = 23800.0 nM 4.62
CHEMBL1643 RIBAVIRIN EC50 = 28400.0 nM 4.55
CHEMBL2171473 EC50 > 50000.0 nM -
CHEMBL2171472 EC50 > 50000.0 nM -
CHEMBL2171471 EC50 > 50000.0 nM -
CHEMBL2171477 EC50 > 50000.0 nM -
CHEMBL2171479 EC50 > 50000.0 nM -
CHEMBL2171468 EC50 > 50000.0 nM -
CHEMBL2171467 EC50 > 50000.0 nM -
CHEMBL2171475 EC50 > 50000.0 nM -
CHEMBL2171480 EC50 > 50000.0 nM -
CHEMBL2171280 EC50 > 50000.0 nM -
CHEMBL1338351 EC50 > 50000.0 nM -
CHEMBL2171279 EC50 > 50000.0 nM -
CHEMBL2171481 EC50 > 50000.0 nM -
CHEMBL2171277 EC50 > 50000.0 nM -
CHEMBL2171482 EC50 > 50000.0 nM -
CHEMBL2171483 EC50 > 50000.0 nM -
CHEMBL2171466 EC50 > 50000.0 nM -