Assay Detail
Binding
CHEMBL2174185
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Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171326 | — | — | 1 | 9.00 |
| CHEMBL2171323 | — | — | 1 | 8.85 |
| CHEMBL2171325 | — | — | 1 | 8.80 |
| CHEMBL2171327 | — | — | 1 | 8.74 |
| CHEMBL2169901 | — | — | 1 | 8.72 |
| CHEMBL2171324 | — | — | 1 | 8.70 |
| CHEMBL258928 | — | — | 1 | 8.55 |
| CHEMBL2171319 | — | — | 1 | 8.33 |
| CHEMBL2171321 | — | — | 1 | 8.28 |
| CHEMBL2171322 | — | — | 1 | 8.25 |
| CHEMBL2171315 | — | — | 1 | 8.21 |
| CHEMBL2171328 | — | — | 1 | 8.18 |
| CHEMBL2171311 | — | — | 1 | 8.12 |
| CHEMBL2171334 | — | — | 1 | 8.08 |
| CHEMBL255304 | — | — | 1 | 8.01 |
| CHEMBL2171333 | — | — | 1 | 7.98 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 7.97 |
| CHEMBL2171320 | — | — | 1 | 7.93 |
| CHEMBL2171314 | — | — | 1 | 7.75 |
| CHEMBL258744 | — | — | 1 | 7.71 |
| CHEMBL2171316 | — | — | 1 | 7.71 |
| CHEMBL2171317 | — | — | 1 | 7.70 |
| CHEMBL2171312 | — | — | 1 | 7.66 |
| CHEMBL258926 | — | — | 1 | 7.64 |
| CHEMBL2171318 | — | — | 1 | 7.63 |
| CHEMBL2171313 | — | — | 1 | 7.60 |
| CHEMBL2171309 | — | — | 1 | 7.58 |
| CHEMBL256919 | — | — | 1 | 7.56 |
| CHEMBL407765 | — | — | 1 | 7.51 |
| CHEMBL255502 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171326 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2171323 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2171325 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2171327 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2169901 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2171324 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL258928 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2171319 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2171321 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2171322 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2171315 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2171328 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL2171311 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2171334 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL255304 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2171333 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL2171320 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL2171314 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL2171316 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL258744 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL2171317 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL2171312 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL258926 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL2171318 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL2171313 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL2171309 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL256919 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL407765 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL255502 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL403083 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL2171308 | — | IC50 | = | 40.3 | nM | 7.39 |
| CHEMBL6622 | ISOSORBIDE DINITRATE | IC50 | - | — | - | |
| CHEMBL2171332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2171331 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2171330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2171329 | — | IC50 | > | 10000.0 | nM | - |