Assay Detail
Binding
CHEMBL2174302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human myeloperoxidase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170241 | — | — | 1 | 6.52 |
| CHEMBL275628 | — | — | 1 | 6.10 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | 5.68 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170241 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL275628 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 3000.0 | nM | 5.52 |