Assay Detail

CHEMBL2175068

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Functional

Cytotoxicity against human DU145 cells measured on day 3 by MTT assay

ChEMBL ↗

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Target

DU-145 (CHEMBL613508) ↗

Open DB target context

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Primary target DU-145

CHEMBL613508

Anchored from Assay target.

Protein identity DU-145

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	DU-145
Confidence	1 — Organism
Curated By	Autocuration

Target

DU-145 (CHEMBL613508) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer.

Akinboye ES, Rosen MD, Denmeade SR, Kwabi-Addo B, Bakare O.
J Med Chem (2012) 55 : 7450 -7459
PubMed 22867001 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Activity	1	-	-
IC50	1	7.48	7.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL493439	EMETINE HYDROCHLORIDE	2.0	2	7.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL493439	EMETINE HYDROCHLORIDE	IC50	=	32.88	nM	7.48
CHEMBL493439	EMETINE HYDROCHLORIDE	Activity		-	—	-