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Assay Detail

CHEMBL2184660

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human SRB1-mediated Hepatitis C virus genotype 2a entry into human HuH7.5 cells by luciferase reporter gene assay
35
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Huh-7
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Scavenger receptor class B member 1 (CHEMBL1914272)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of ITX 4520: a highly potent orally bioavailable hepatitis C virus entry inhibitor.
Mittapalli GK, Zhao F, Jackson A, Gao H, Lee H, Chow S, Kaur MP, Nguyen N, Zamboni R, McKelvy J, Wong-Staal F, Macdonald JE.
Bioorg Med Chem Lett (2012) 22 : 4955 -4961
PubMed 22784640 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 8.16 8.82
IC90 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1914885 1 8.82
CHEMBL2179502 1 8.82
CHEMBL2179514 1 8.82
CHEMBL2179515 1 8.82
CHEMBL2179485 1 8.82
CHEMBL2179509 1 8.82
CHEMBL2179511 1 8.82
CHEMBL2179508 1 8.82
CHEMBL2179507 1 8.82
CHEMBL2179504 1 8.82
CHEMBL2179510 2 8.82
CHEMBL2179501 1 8.82
CHEMBL2179500 1 8.82
CHEMBL2179499 1 8.82
CHEMBL2179493 1 8.82
CHEMBL2179497 1 8.30
CHEMBL2179512 1 8.30
CHEMBL2179106 1 8.30
CHEMBL2179488 1 8.00
CHEMBL2177128 1 7.82
CHEMBL2179487 1 7.82
CHEMBL2179486 1 7.82
CHEMBL2179494 1 7.82
CHEMBL2179498 1 7.82
CHEMBL2179506 1 7.82
CHEMBL2179513 1 7.82
CHEMBL2179490 1 7.52
CHEMBL2179496 1 7.30
CHEMBL2179495 1 7.30
CHEMBL2179503 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2179499 IC50 = 1.5 nM 8.82
CHEMBL2179500 IC50 = 1.5 nM 8.82
CHEMBL2179501 IC50 = 1.5 nM 8.82
CHEMBL2179502 IC50 = 1.5 nM 8.82
CHEMBL2179504 IC50 = 1.5 nM 8.82
CHEMBL2179507 IC50 = 1.5 nM 8.82
CHEMBL2179508 IC50 = 1.5 nM 8.82
CHEMBL2179510 IC50 = 1.5 nM 8.82
CHEMBL2179511 IC50 = 1.5 nM 8.82
CHEMBL2179493 IC50 = 1.5 nM 8.82
CHEMBL2179514 IC50 = 1.5 nM 8.82
CHEMBL2179515 IC50 = 1.5 nM 8.82
CHEMBL2179485 IC50 = 1.5 nM 8.82
CHEMBL1914885 IC50 = 1.5 nM 8.82
CHEMBL2179509 IC50 = 1.5 nM 8.82
CHEMBL2179106 IC50 = 5.0 nM 8.30
CHEMBL2179512 IC50 = 5.0 nM 8.30
CHEMBL2179497 IC50 = 5.0 nM 8.30
CHEMBL2179488 IC50 = 10.0 nM 8.00
CHEMBL2179486 IC50 = 15.0 nM 7.82
CHEMBL2179513 IC50 = 15.0 nM 7.82
CHEMBL2179506 IC50 = 15.0 nM 7.82
CHEMBL2179498 IC50 = 15.0 nM 7.82
CHEMBL2177128 IC50 = 15.0 nM 7.82
CHEMBL2179494 IC50 = 15.0 nM 7.82
CHEMBL2179487 IC50 = 15.0 nM 7.82
CHEMBL2179490 IC50 = 30.0 nM 7.52
CHEMBL2179503 IC50 = 50.0 nM 7.30
CHEMBL2179496 IC50 = 50.0 nM 7.30
CHEMBL2179495 IC50 = 50.0 nM 7.30
CHEMBL2179505 IC50 = 50.0 nM 7.30
CHEMBL2179492 IC50 = 50.0 nM 7.30
CHEMBL2179489 IC50 = 50.0 nM 7.30
CHEMBL2179491 IC50 = 500.0 nM 6.30
CHEMBL2179510 IC90 = 50.0 nM -