Assay Detail
Functional
CHEMBL2184974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against NNRTI-resistant HIV1 harboring reverse transcriptase Y188L mutant infected in human MT4 cells assessed as inhibition of viral replication after 72 hrs by HeLa-CD4-LTR-beta-gal assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.89 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180972 | — | — | 1 | 9.30 |
| CHEMBL2180971 | — | — | 1 | 9.05 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.05 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 8.43 |
| CHEMBL2180964 | — | — | 1 | 8.25 |
| CHEMBL2180965 | — | — | 1 | 8.15 |
| CHEMBL2180966 | — | — | 1 | 7.96 |
| CHEMBL203420 | — | — | 1 | 7.75 |
| CHEMBL2180969 | — | — | 1 | 7.62 |
| CHEMBL2180967 | — | — | 1 | 7.12 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.80 |
| CHEMBL2180968 | — | — | 1 | 6.62 |
| CHEMBL2180963 | — | — | 1 | 6.50 |
| CHEMBL2180958 | — | — | 1 | - |
| CHEMBL2180957 | — | — | 1 | - |
| CHEMBL2180956 | — | — | 1 | - |
| CHEMBL2180959 | — | — | 1 | - |
| CHEMBL2180960 | — | — | 1 | - |
| CHEMBL2180961 | — | — | 1 | - |
| CHEMBL2180962 | — | — | 1 | - |
| CHEMBL2180970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180972 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2180971 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2180964 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2180965 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2180966 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL203420 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2180969 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2180967 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL2180968 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2180963 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2180958 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180957 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180956 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180959 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180960 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180961 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180962 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2180970 | — | EC50 | > | 1000.0 | nM | - |