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Assay Detail

CHEMBL2185274

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human Jurkat cells after 4 days by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.
Diao Y, Lu W, Jin H, Zhu J, Han L, Xu M, Gao R, Shen X, Zhao Z, Liu X, Xu Y, Huang J, Li H.
J Med Chem (2012) 55 : 8341 -8349
PubMed 22984987 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.75 5.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1076869 1 5.97
CHEMBL2178108 1 5.27
CHEMBL2177115 1 4.80
CHEMBL2178107 1 4.58
CHEMBL973 TERIFLUNOMIDE 4.0 1 4.57
CHEMBL2178106 1 4.52
CHEMBL2178105 1 4.36
CHEMBL2178112 1 4.34
CHEMBL2178111 1 4.34
CHEMBL1373924 1 -
CHEMBL2178110 1 -
CHEMBL2178109 1 -
CHEMBL2178104 1 -
CHEMBL160 CYCLOSPORINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1076869 IC50 = 1070.0 nM 5.97
CHEMBL2178108 IC50 = 5390.0 nM 5.27
CHEMBL2177115 IC50 = 15740.0 nM 4.80
CHEMBL2178107 IC50 = 26320.0 nM 4.58
CHEMBL973 TERIFLUNOMIDE IC50 = 26650.0 nM 4.57
CHEMBL2178106 IC50 = 30130.0 nM 4.52
CHEMBL2178105 IC50 = 43540.0 nM 4.36
CHEMBL2178112 IC50 = 45740.0 nM 4.34
CHEMBL2178111 IC50 = 45730.0 nM 4.34
CHEMBL1373924 IC50 > 100000.0 nM -
CHEMBL2178110 IC50 > 100000.0 nM -
CHEMBL2178109 IC50 > 100000.0 nM -
CHEMBL2178104 IC50 > 100000.0 nM -
CHEMBL160 CYCLOSPORINE IC50 > 10000.0 nM -