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Assay Detail

CHEMBL2186428

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
Lizzi F, Veronesi G, Belluti F, Bergamini C, López-Sánchez A, Kaiser M, Brun R, Krauth-Siegel RL, Hall DG, Rivas L, Bolognesi ML.
J Med Chem (2012) 55 : 10490 -10500
PubMed 23153330 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.45 8.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 8.77
CHEMBL255731 1 6.00
CHEMBL2179005 1 5.31
CHEMBL2179000 1 5.30
CHEMBL2177124 1 5.25
CHEMBL256155 1 5.23
CHEMBL2179006 1 5.20
CHEMBL2179002 1 5.19
CHEMBL2179001 1 5.15
CHEMBL2179004 1 5.14
CHEMBL2178999 1 5.04
CHEMBL2179003 1 5.04
CHEMBL2178998 1 4.96
CHEMBL166 MELARSOPROL 3.0 1 4.74
CHEMBL125 MILTEFOSINE 4.0 1 -
CHEMBL110 BENZNIDAZOLE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 1.7 nM 8.77
CHEMBL255731 IC50 = 990.0 nM 6.00
CHEMBL2179005 IC50 = 4870.0 nM 5.31
CHEMBL2179000 IC50 = 5040.0 nM 5.30
CHEMBL2177124 IC50 = 5600.0 nM 5.25
CHEMBL256155 IC50 = 5920.0 nM 5.23
CHEMBL2179006 IC50 = 6290.0 nM 5.20
CHEMBL2179002 IC50 = 6460.0 nM 5.19
CHEMBL2179001 IC50 = 7050.0 nM 5.15
CHEMBL2179004 IC50 = 7210.0 nM 5.14
CHEMBL2178999 IC50 = 9100.0 nM 5.04
CHEMBL2179003 IC50 = 9180.0 nM 5.04
CHEMBL2178998 IC50 = 11100.0 nM 4.96
CHEMBL166 MELARSOPROL IC50 = 18300.0 nM 4.74
CHEMBL125 MILTEFOSINE IC50 = 143100.0 nM -
CHEMBL110 BENZNIDAZOLE IC50 > 384000.0 nM -