Assay Detail
ADMET
CHEMBL2186606
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Inhibition of CYP3A4
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.59 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178249 | — | — | 1 | 6.70 |
| CHEMBL2178806 | — | — | 1 | 5.34 |
| CHEMBL2178258 | — | — | 1 | 5.17 |
| CHEMBL2178253 | — | — | 1 | 5.14 |
| CHEMBL2178247 | — | — | 1 | - |
| CHEMBL2178807 | — | — | 1 | - |
| CHEMBL2178254 | — | — | 1 | - |
| CHEMBL2178252 | — | — | 1 | - |
| CHEMBL2178251 | — | — | 1 | - |
| CHEMBL2178250 | — | — | 1 | - |
| CHEMBL2178248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178249 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2178806 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2178258 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2178253 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2178247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2178807 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2178254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2178252 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2178251 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2178250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2178248 | — | IC50 | > | 10000.0 | nM | - |