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Assay Detail

CHEMBL2187070

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter
38
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.
Baraldi PG, Preti D, Borea PA, Varani K.
J Med Chem (2012) 55 : 5676 -5703
PubMed 22468757 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 37 6.47 8.15
IC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122396 1 8.15
CHEMBL2181971 1 7.85
CHEMBL322250 1 7.30
CHEMBL193692 1 7.30
CHEMBL2181972 1 7.16
CHEMBL2181970 1 6.98
CHEMBL2177153 1 6.96
CHEMBL193421 1 6.91
CHEMBL88147 1 6.64
CHEMBL175543 1 6.58
CHEMBL2181973 1 6.49
CHEMBL332091 1 6.46
CHEMBL2181977 1 6.37
CHEMBL186113 GW-328267 1.0 1 6.00
CHEMBL1625681 1 5.79
CHEMBL2181965 1 5.75
CHEMBL398587 1 5.42
CHEMBL2181967 1 5.33
CHEMBL198779 1 5.10
CHEMBL2181969 1 4.92
CHEMBL363419 1 -
CHEMBL2181976 1 -
CHEMBL188035 1 -
CHEMBL434534 1 -
CHEMBL371404 1 -
CHEMBL339066 1 -
CHEMBL2181975 1 -
CHEMBL589080 1 -
CHEMBL89093 1 -
CHEMBL128929 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122396 Ki = 7.0 nM 8.15
CHEMBL2181971 Ki = 14.0 nM 7.85
CHEMBL193692 Ki = 50.0 nM 7.30
CHEMBL322250 Ki = 50.0 nM 7.30
CHEMBL2181972 Ki = 70.0 nM 7.16
CHEMBL2181970 Ki = 104.0 nM 6.98
CHEMBL2177153 Ki = 110.0 nM 6.96
CHEMBL193421 Ki = 124.0 nM 6.91
CHEMBL88147 Ki = 231.0 nM 6.64
CHEMBL175543 Ki = 260.0 nM 6.58
CHEMBL2181973 Ki = 325.0 nM 6.49
CHEMBL332091 Ki = 350.0 nM 6.46
CHEMBL2181977 Ki = 430.0 nM 6.37
CHEMBL186113 GW-328267 Ki = 1000.0 nM 6.00
CHEMBL1625681 Ki = 1640.0 nM 5.79
CHEMBL2181965 Ki = 1800.0 nM 5.75
CHEMBL398587 Ki = 3800.0 nM 5.42
CHEMBL2181967 Ki = 4640.0 nM 5.33
CHEMBL198779 Ki = 8000.0 nM 5.10
CHEMBL2181969 Ki = 12100.0 nM 4.92
CHEMBL128929 Ki > 10000.0 nM -
CHEMBL2181966 Ki > 100000.0 nM -
CHEMBL2181968 Ki > 10000.0 nM -
CHEMBL2181964 Ki > 10000.0 nM -
CHEMBL113420 Ki > 10000.0 nM -
CHEMBL123705 Ki > 10000.0 nM -
CHEMBL99178 Ki > 10000.0 nM -
CHEMBL211862 Ki > 10000.0 nM -
CHEMBL333799 Ki > 10000.0 nM -
CHEMBL363419 Ki > 10000.0 nM -
CHEMBL89093 Ki > 10000.0 nM -
CHEMBL589080 Ki > 10000.0 nM -
CHEMBL2181975 Ki > 10000.0 nM -
CHEMBL339066 IC50 > 10000.0 nM -
CHEMBL371404 Ki > 1000.0 nM -
CHEMBL434534 Ki > 1000.0 nM -
CHEMBL188035 Ki > 1000.0 nM -
CHEMBL2181976 Ki > 666.0 nM -