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Assay Detail

CHEMBL2189040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity assessed as scavenging of morpholino sydononimine based nitric oxide release by chemiluminescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Yanovsky I, Finkin-Groner E, Zaikin A, Lerman L, Shalom H, Zeeli S, Weill T, Ginsburg I, Nudelman A, Weinstock M.
J Med Chem (2012) 55 : 10700 -10715
PubMed 23151013 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 5.76 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2181473 1 6.60
CHEMBL2177715 1 6.24
CHEMBL50 QUERCETIN 3.0 1 6.21
CHEMBL2177148 1 5.87
CHEMBL2181474 1 5.86
CHEMBL3217012 1 5.67
CHEMBL2177718 1 5.66
CHEMBL2177708 1 5.63
CHEMBL2177704 1 5.50
CHEMBL2181469 1 5.49
CHEMBL2181475 1 5.34
CHEMBL2177716 1 5.07
CHEMBL2177714 1 -
CHEMBL2177111 1 -
CHEMBL2177712 1 -
CHEMBL2177711 1 -
CHEMBL2177710 1 -
CHEMBL2177709 1 -
CHEMBL45 MELATONIN 4.0 1 -
CHEMBL2177707 1 -
CHEMBL2177706 1 -
CHEMBL2177705 1 -
CHEMBL2181468 1 -
CHEMBL2177703 1 -
CHEMBL2177702 1 -
CHEMBL2177701 1 -
CHEMBL2177700 1 -
CHEMBL2177698 1 -
CHEMBL288114 GALLIC ACID 2.0 1 -
CHEMBL2181470 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2181473 IC50 = 250.0 nM 6.60
CHEMBL2177715 IC50 = 570.0 nM 6.24
CHEMBL50 QUERCETIN IC50 = 610.0 nM 6.21
CHEMBL2177148 IC50 = 1340.0 nM 5.87
CHEMBL2181474 IC50 = 1380.0 nM 5.86
CHEMBL3217012 IC50 = 2130.0 nM 5.67
CHEMBL2177718 IC50 = 2180.0 nM 5.66
CHEMBL2177708 IC50 = 2360.0 nM 5.63
CHEMBL2177704 IC50 = 3180.0 nM 5.50
CHEMBL2181469 IC50 = 3250.0 nM 5.49
CHEMBL2181475 IC50 = 4550.0 nM 5.34
CHEMBL2177716 IC50 = 8490.0 nM 5.07
CHEMBL2177717 IC50 - -
CHEMBL2177724 IC50 - -
CHEMBL2177714 IC50 - -
CHEMBL2177111 IC50 - -
CHEMBL2177712 IC50 - -
CHEMBL2177711 IC50 - -
CHEMBL2177710 IC50 - -
CHEMBL2177709 IC50 - -
CHEMBL45 MELATONIN IC50 = 1024000.0 nM -
CHEMBL2177707 IC50 - -
CHEMBL2177706 IC50 - -
CHEMBL2177705 IC50 - -
CHEMBL2181468 IC50 - -
CHEMBL2177703 IC50 - -
CHEMBL2177702 IC50 - -
CHEMBL2177701 IC50 - -
CHEMBL2177700 IC50 - -
CHEMBL2177698 IC50 - -
CHEMBL288114 GALLIC ACID IC50 - -
CHEMBL2181470 IC50 - -