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Compound Detail

CHEMBL2181469

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CN1CC(CCC(=O)O)c2ccc(O)cc21.Cl

Basic Information

ChEMBL ID CHEMBL2181469
Phase Preclinical
Structure Type MOL
InChI Key MDNWTWQVTIHUQI-UHFFFAOYSA-N
Parent Compound CHEMBL2221097
Active Moiety CHEMBL2221097
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

221.3
MW (Da)
1.79
ALogP
3
HBA
2
HBD
60.8
PSA (Ų)
0.82
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H16ClNO3
MW 257.72
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness 0.57

Activity Summary

IC50 2 meas. best 6.08

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 6.08 6.08 840.0 1
No relevant target
CHEMBL2362975
IC50 5.49 5.49 3250.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23151013 10.1021/jm301411g NON-PROTEIN TARGET 2
23151013 10.1021/jm301411g Radical scavenging activity 1
23151013 10.1021/jm301411g No relevant target 1

Data from ChEMBL 36 via Core Engine