Assay Detail
Binding
CHEMBL2189108
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Displacement of [3H]DSLET from delta opioid receptor in rat brain membranes after 2 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.67 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782140 | — | — | 1 | 9.22 |
| CHEMBL2181191 | — | — | 1 | 8.50 |
| CHEMBL2181199 | — | — | 1 | 8.40 |
| CHEMBL2181195 | — | — | 1 | 8.30 |
| CHEMBL2181193 | — | — | 1 | 8.13 |
| CHEMBL2181201 | — | — | 1 | 7.82 |
| CHEMBL2181197 | — | — | 1 | 7.80 |
| CHEMBL2181194 | — | — | 1 | 7.41 |
| CHEMBL2181196 | — | — | 1 | 7.41 |
| CHEMBL2181200 | — | — | 1 | 7.30 |
| CHEMBL2181192 | — | — | 1 | 7.25 |
| CHEMBL2181198 | — | — | 1 | 6.51 |
| CHEMBL2181202 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782140 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2181191 | — | Ki | = | 3.18 | nM | 8.50 |
| CHEMBL2181199 | — | Ki | = | 3.98 | nM | 8.40 |
| CHEMBL2181195 | — | Ki | = | 5.03 | nM | 8.30 |
| CHEMBL2181193 | — | Ki | = | 7.46 | nM | 8.13 |
| CHEMBL2181201 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL2181197 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2181194 | — | Ki | = | 38.6 | nM | 7.41 |
| CHEMBL2181196 | — | Ki | = | 39.2 | nM | 7.41 |
| CHEMBL2181200 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL2181192 | — | Ki | = | 56.9 | nM | 7.25 |
| CHEMBL2181198 | — | Ki | = | 309.0 | nM | 6.51 |
| CHEMBL2181202 | — | Ki | = | 2100.0 | nM | 5.68 |