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Assay Detail

CHEMBL2211267

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP2D6
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cytochrome P450 2D6 (CHEMBL289)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Pechulis AD, Beck JP, Curry MA, Wolf MA, Harms AE, Xi N, Opalka C, Sweet MP, Yang Z, Vellekoop AS, Klos AM, Crocker PJ, Hassler C, Laws M, Kitchen DB, Smith MA, Olson RE, Liu S, Molino BF.
Bioorg Med Chem Lett (2012) 22 : 7219 -7222
PubMed 23084899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.32 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2206509 1 6.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2206509 IC50 = 480.0 nM 6.32