Assay Detail
Binding
CHEMBL2211271
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Inhibition of SERT
35
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 6.22 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206523 | — | — | 2 | 7.60 |
| CHEMBL2206525 | — | — | 1 | 7.09 |
| CHEMBL2206526 | — | — | 1 | 6.99 |
| CHEMBL2206533 | — | — | 1 | 6.96 |
| CHEMBL2206510 | — | — | 1 | 6.94 |
| CHEMBL2206527 | — | — | 1 | 6.93 |
| CHEMBL2206535 | — | — | 1 | 6.92 |
| CHEMBL2206509 | — | — | 1 | 6.64 |
| CHEMBL2206524 | — | — | 1 | 6.58 |
| CHEMBL2206534 | — | — | 1 | 6.54 |
| CHEMBL2206507 | — | — | 1 | 6.47 |
| CHEMBL2206519 | — | — | 1 | 6.45 |
| CHEMBL2206532 | — | — | 1 | 6.32 |
| CHEMBL2206531 | — | — | 1 | 6.28 |
| CHEMBL2206536 | — | — | 1 | 6.23 |
| CHEMBL2206517 | — | — | 1 | 6.12 |
| CHEMBL2206529 | — | — | 1 | 6.08 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 2 | 6.03 |
| CHEMBL2206516 | — | — | 1 | 5.91 |
| CHEMBL2206512 | — | — | 1 | 5.84 |
| CHEMBL2206518 | — | — | 1 | 5.84 |
| CHEMBL2206530 | — | — | 1 | 5.83 |
| CHEMBL2206515 | — | — | 1 | 5.82 |
| CHEMBL400964 | — | — | 1 | 5.81 |
| CHEMBL2206521 | — | — | 1 | 5.80 |
| CHEMBL207867 | — | — | 1 | 5.76 |
| CHEMBL2206514 | — | — | 1 | 5.69 |
| CHEMBL2206508 | — | — | 1 | 5.67 |
| CHEMBL2206511 | — | — | 1 | 5.64 |
| CHEMBL2206520 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206523 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2206525 | — | Ki | = | 81.7 | nM | 7.09 |
| CHEMBL2206526 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL2206533 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL2206510 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL2206527 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL2206535 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL2206509 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL2206524 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL2206534 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL2206507 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL2206519 | — | Ki | = | 352.0 | nM | 6.45 |
| CHEMBL2206532 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL2206531 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL2206536 | — | Ki | = | 594.0 | nM | 6.23 |
| CHEMBL2206517 | — | Ki | = | 767.0 | nM | 6.12 |
| CHEMBL2206529 | — | Ki | = | 822.0 | nM | 6.08 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 935.0 | nM | 6.03 |
| CHEMBL2206516 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL2206512 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL2206518 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL2206530 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL2206515 | — | Ki | = | 1510.0 | nM | 5.82 |
| CHEMBL400964 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL2206521 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL207867 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL2206523 | — | Ki | = | 1776.0 | nM | 5.75 |
| CHEMBL2206514 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 2057.0 | nM | 5.69 |
| CHEMBL2206508 | — | Ki | = | 2149.0 | nM | 5.67 |
| CHEMBL2206511 | — | Ki | = | 2310.0 | nM | 5.64 |
| CHEMBL2206520 | — | Ki | = | 2850.0 | nM | 5.54 |
| CHEMBL2206513 | — | Ki | = | 4224.0 | nM | 5.37 |
| CHEMBL2206522 | — | Ki | - | — | - | |
| CHEMBL2206528 | — | Ki | - | — | - |