Assay Detail
Functional
CHEMBL2212508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL60/A cells after 18 hrs by annexin-V labeling-based flow cytometry
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL60/A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.04 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | — | 1 | 5.43 |
| CHEMBL4298697 | — | — | 1 | 5.39 |
| CHEMBL86416 | COSTUNOLIDE | — | 1 | 5.24 |
| CHEMBL2206426 | — | — | 1 | 5.23 |
| CHEMBL449579 | MICHELIOLIDE | — | 1 | 5.21 |
| CHEMBL2206433 | — | — | 1 | 5.19 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.17 |
| CHEMBL2206428 | — | — | 1 | 5.17 |
| CHEMBL2206435 | — | — | 1 | 5.00 |
| CHEMBL2206427 | — | — | 1 | 4.99 |
| CHEMBL2206432 | — | — | 1 | 4.95 |
| CHEMBL2206436 | — | — | 1 | 4.75 |
| CHEMBL2206429 | DIMETHYLAMINOMICHELIOLIDE HYDROCHLORIDE | — | 1 | 4.67 |
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 1 | 4.63 |
| CHEMBL275748 | TULIPALINE A | — | 1 | 4.54 |
| CHEMBL2206422 | — | — | 1 | - |
| CHEMBL2206423 | — | — | 1 | - |
| CHEMBL2206424 | — | — | 1 | - |
| CHEMBL2206425 | — | — | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
| CHEMBL87967 | ITACONIC ANHYDRIDE | — | 1 | - |
| CHEMBL2205104 | SARMENTINE | — | 1 | - |
| CHEMBL2206430 | — | — | 1 | - |
| CHEMBL2206434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4298697 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL86416 | COSTUNOLIDE | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2206426 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL449579 | MICHELIOLIDE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2206433 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2206428 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2206435 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2206427 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2206432 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL2206436 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL2206429 | DIMETHYLAMINOMICHELIOLIDE HYDROCHLORIDE | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL275748 | TULIPALINE A | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL2206422 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2206423 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2206424 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2206425 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC50 | > | 50000.0 | nM | - |
| CHEMBL87967 | ITACONIC ANHYDRIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL2205104 | SARMENTINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL2206430 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2206434 | — | IC50 | > | 50000.0 | nM | - |