Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL275748

TULIPALINE A
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace

Basic Information

ChEMBL ID CHEMBL275748
Name TULIPALINE A
Phase Preclinical
Structure Type MOL
InChI Key GSLDEZOOOSBFGP-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
20
Publications
0
Known Names

Molecular Properties

98.1
MW (Da)
0.49
ALogP
2
HBA
0
HBD
26.3
PSA (Ų)
0.33
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C5H6O2
MW 98.10
Aromatic Rings 0
Heavy Atoms 7
NP-Likeness 1.29

Activity Summary

IC50 2 meas. best 4.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
 IC50 4.54 4.54 28800.0 1
HL-60
CHEMBL383
 IC50 4.46 4.46 35000.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 25.0 hr -

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET IC50 = 28800.0 nM 4.54 Cytotoxicity against human HL60/A cells after 18 hrs by annexin-V labeling-based... 22985027
HL-60 IC50 = 35000.0 nM 4.46 Cytotoxicity against human HL60 cells after 18 hrs by annexin-V labeling-based f... 22985027

Literature References

PubMed DOI Target Context # Activities
10509909 10.1016/s0960-894x(99)00442-4 Rattus norvegicus 15
3701795 10.1021/jm00155a046 Cavia porcellus 12
27389105 10.1271/bbb.63.760 Frankliniella intonsa 12
27389105 10.1271/bbb.63.760 Thrips palmi 12
27389105 10.1271/bbb.63.760 Frankliniella occidentalis 6
9214736 10.1021/np970013z Bacillus subtilis 4
9214736 10.1021/np970013z Escherichia coli 4
9214736 10.1021/np970013z Pseudomonas aeruginosa 4
9214736 10.1021/np970013z Trichophyton mentagrophytes 4
9214736 10.1021/np970013z ADMET 4
15482940 10.1016/j.bmcl.2004.08.048 CAKI-1 4
27389105 10.1271/bbb.63.760 Nilaparvata lugens 4
27389105 10.1271/bbb.63.760 Spodoptera litura 4
27389105 10.1271/bbb.63.760 Plutella xylostella 4
7411546 10.1021/jm00183a013 Cavia porcellus 4
20729083 10.1016/j.bmcl.2010.07.139 Unchecked 3
38686671 10.1021/acs.jmedchem.4c00357 NACHT, LRR and PYD domains-containing protein 3 2
20729083 10.1016/j.bmcl.2010.07.139 Escherichia coli 2
15482940 10.1016/j.bmcl.2004.08.048 Unchecked 1
9214736 10.1021/np970013z P388 1

Data from ChEMBL 36 via Core Engine