Assay Detail
Binding
CHEMBL2213380
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Displacement of [3H]spiperone from rat cloned dopamine D2L receptor expressed in HEK-293 cells by competition binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206265 | — | — | 1 | 8.70 |
| CHEMBL2206264 | — | — | 1 | 8.60 |
| CHEMBL2206273 | — | — | 1 | 8.41 |
| CHEMBL2206272 | — | — | 1 | 8.23 |
| CHEMBL2206266 | — | — | 1 | 7.96 |
| CHEMBL2206269 | — | — | 1 | 7.80 |
| CHEMBL2206267 | — | — | 1 | 7.26 |
| CHEMBL269004 | — | — | 1 | 7.23 |
| CHEMBL2203317 | — | — | 1 | 7.16 |
| CHEMBL2206270 | — | — | 1 | 7.16 |
| CHEMBL2206271 | — | — | 1 | 7.12 |
| CHEMBL2206268 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206265 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2206264 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2206273 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2206272 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL2206266 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2206269 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2206267 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL269004 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2203317 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL2206270 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2206271 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL2206268 | — | Ki | = | 140.0 | nM | 6.85 |