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Assay Detail

CHEMBL2214290

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Vaccinia virus
Cell Type HEL
Confidence 1 — Organism
Curated By Autocuration

Target

Vaccinia virus (CHEMBL613493)
Type ORGANISM
Organism Vaccinia virus

Publication

Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
Sipos A, Török Z, Rőth E, Kiss-Szikszai A, Batta G, Bereczki I, Fejes Z, Borbás A, Ostorházi E, Rozgonyi F, Naesens L, Herczegh P.
Bioorg Med Chem Lett (2012) 22 : 7092 -7096
PubMed 23099097 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 4.55 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31634 BRIVUDINE 2.0 1 5.00
CHEMBL2207649 1 5.00
CHEMBL5314375 CIDOFOVIR 4.0 1 4.68
CHEMBL2203331 1 4.35
CHEMBL2207652 1 4.35
CHEMBL2207651 1 4.35
CHEMBL2207653 1 4.33
CHEMBL2207647 1 4.33
CHEMBL182 GANCICLOVIR 4.0 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -
CHEMBL2207650 1 -
CHEMBL2207648 1 -
CHEMBL2207646 1 -
CHEMBL2207645 1 -
CHEMBL2207644 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31634 BRIVUDINE EC50 = 10000.0 nM 5.00
CHEMBL2207649 EC50 = 10000.0 nM 5.00
CHEMBL5314375 CIDOFOVIR EC50 = 21000.0 nM 4.68
CHEMBL2203331 EC50 = 45000.0 nM 4.35
CHEMBL2207652 EC50 = 45000.0 nM 4.35
CHEMBL2207651 EC50 = 45000.0 nM 4.35
CHEMBL2207653 EC50 = 47000.0 nM 4.33
CHEMBL2207647 EC50 = 47000.0 nM 4.33
CHEMBL182 GANCICLOVIR EC50 > 100000.0 nM -
CHEMBL184 ACYCLOVIR EC50 >= 250000.0 nM -
CHEMBL2207650 EC50 > 100000.0 nM -
CHEMBL2207648 EC50 > 20000.0 nM -
CHEMBL2207646 EC50 >= 58000.0 nM -
CHEMBL2207645 EC50 > 20000.0 nM -
CHEMBL2207644 EC50 > 100000.0 nM -