Assay Detail
Functional
CHEMBL2214768
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Inhibition of JAK2 in HEL 92.1.7 cells xenografted in po dosed nude mouse assessed as inhibition of STAT3 phosphorylation after 4 hrs
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.89 | 4.89 |
| ED50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2208034 | — | — | 2 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2208034 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2208034 | — | ED50 | = | 210.0 | mg.kg-1 | - |