Assay Detail
ADMET
CHEMBL2215826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2D6 using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy- 4-methylcoumarin after 45 mins by fluorescence spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205043 | — | — | 1 | 6.40 |
| CHEMBL2204356 | — | — | 1 | 6.30 |
| CHEMBL2204359 | — | — | 1 | 6.05 |
| CHEMBL2204363 | — | — | 1 | 5.82 |
| CHEMBL2205045 | — | — | 1 | 5.57 |
| CHEMBL2205054 | — | — | 1 | 5.55 |
| CHEMBL2204357 | — | — | 1 | 5.48 |
| CHEMBL2204360 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205043 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2204356 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2204359 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2204363 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2205045 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2205054 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2204357 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2204360 | — | IC50 | = | 9800.0 | nM | 5.01 |