Assay Detail
ADMET
CHEMBL2215827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2C9 using dibenzylfluorescein after 45 mins by fluorescence spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.43 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205043 | — | — | 1 | 4.51 |
| CHEMBL2204359 | — | — | 1 | 4.47 |
| CHEMBL2205054 | — | — | 1 | 4.47 |
| CHEMBL2204360 | — | — | 1 | 4.41 |
| CHEMBL2204363 | — | — | 1 | 4.40 |
| CHEMBL2204357 | — | — | 1 | 4.40 |
| CHEMBL2204356 | — | — | 1 | 4.40 |
| CHEMBL2205045 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205043 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2204359 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2205054 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2204360 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL2204363 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2204357 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2204356 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2205045 | — | IC50 | = | 40000.0 | nM | 4.40 |