Assay Detail
Binding
CHEMBL2215841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation counting
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.51 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.41 |
| CHEMBL2204361 | — | — | 1 | 8.37 |
| CHEMBL2204357 | — | — | 1 | 8.36 |
| CHEMBL2205053 | — | — | 1 | 8.33 |
| CHEMBL2204359 | — | — | 1 | 8.28 |
| CHEMBL2204360 | — | — | 1 | 8.28 |
| CHEMBL2205054 | — | — | 1 | 8.24 |
| CHEMBL2205046 | — | — | 1 | 8.16 |
| CHEMBL2204358 | — | — | 1 | 8.12 |
| CHEMBL2205037 | — | — | 1 | 8.10 |
| CHEMBL2205042 | — | — | 1 | 8.10 |
| CHEMBL2205038 | — | — | 1 | 8.02 |
| CHEMBL2204363 | — | — | 1 | 8.01 |
| CHEMBL2204362 | — | — | 1 | 7.96 |
| CHEMBL2205043 | — | — | 1 | 7.89 |
| CHEMBL2205052 | — | — | 1 | 7.82 |
| CHEMBL2204356 | — | — | 1 | 7.77 |
| CHEMBL2205045 | — | — | 1 | 7.75 |
| CHEMBL2205040 | — | — | 1 | 7.70 |
| CHEMBL2204365 | — | — | 1 | 7.60 |
| CHEMBL2204355 | — | — | 1 | 7.43 |
| CHEMBL2204364 | — | — | 1 | 7.36 |
| CHEMBL2205051 | — | — | 1 | 7.29 |
| CHEMBL2205048 | — | — | 1 | 7.28 |
| CHEMBL2205049 | — | — | 1 | 7.27 |
| CHEMBL2205044 | — | — | 1 | 7.17 |
| CHEMBL2205039 | — | — | 1 | 7.17 |
| CHEMBL2205034 | — | — | 1 | 6.89 |
| CHEMBL2205036 | — | — | 1 | 6.82 |
| CHEMBL2205031 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL2204361 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL2204357 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2205053 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2204359 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2204360 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2205054 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2205046 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2204358 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2205037 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL2205042 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2205038 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2204363 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL2204362 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2205043 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2205052 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2204356 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2205045 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2205040 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2204365 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2204355 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2204364 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2205051 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2205048 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2205049 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2205044 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2205039 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2205034 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2205036 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2205031 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2205035 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2205050 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2205041 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2205032 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2205033 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2205047 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL49 | BUSPIRONE | IC50 | > | 1000.0 | nM | - |
| CHEMBL46 | ONDANSETRON | IC50 | > | 2000.0 | nM | - |