Assay Detail
Functional
CHEMBL2216657
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Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chikungunya virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.80 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 1 | 8.54 |
| CHEMBL170518 | PROSTRATIN | — | 1 | 5.58 |
| CHEMBL2373592 | — | — | 1 | 5.55 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.96 |
| CHEMBL2208234 | TRIGOWIIN A | — | 1 | 4.36 |
| CHEMBL124518 | PHORBOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL170518 | PROSTRATIN | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2373592 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2208234 | TRIGOWIIN A | EC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL124518 | PHORBOL | EC50 | > | 343000.0 | nM | - |