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Compound Detail

CHEMBL2373592

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CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)C(=O)C(C)=C[C@@H]23)[C@H]2C(C)(C)[C@]12OC(C)=O

Basic Information

ChEMBL ID CHEMBL2373592
Phase Preclinical
Structure Type MOL
InChI Key PHEDXBVPIONUQT-AFPOFPRFSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

616.8
MW (Da)
5.75
ALogP
8
HBA
3
HBD
130.4
PSA (Ų)
0.12
QED
2
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C36H56O8
MW 616.84
Aromatic Rings 0
Heavy Atoms 44
NP-Likeness 2.38

Activity Summary

EC50 2 meas. best 5.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 5.55 5.55 2800.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25970561 10.1021/acs.jnatprod.5b00073 Unchecked 3
23062825 10.1016/j.bmc.2012.09.040 Acetylcholinesterase 1
23062825 10.1016/j.bmc.2012.09.040 Cholinesterase 1
23215460 10.1021/np300637t Semliki Forest virus 1
23215460 10.1021/np300637t Sindbis virus 1
23215460 10.1021/np300637t Unchecked 1
23215460 10.1021/np300637t NON-PROTEIN TARGET 1
23215460 10.1021/np300637t Vero 1
25970561 10.1021/acs.jnatprod.5b00073 NON-PROTEIN TARGET 1
25970561 10.1021/acs.jnatprod.5b00073 Human immunodeficiency virus 1 1
25970561 10.1021/acs.jnatprod.5b00073 Human immunodeficiency virus 2 1

Data from ChEMBL 36 via Core Engine