Assay Detail
Functional
CHEMBL2317052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.05 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458673 | — | — | 1 | 7.77 |
| CHEMBL2316626 | — | — | 1 | 7.30 |
| CHEMBL2316631 | — | — | 1 | 6.09 |
| CHEMBL2316628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458673 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2316626 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2316631 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL2316628 | — | IC50 | > | 100000.0 | nM | - |