Assay Detail
Binding
CHEMBL2317633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human M5 muscarinic receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.10 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12098 | SCH-211803 | — | 1 | 7.07 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.90 |
| CHEMBL215180 | — | — | 1 | 5.46 |
| CHEMBL326450 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12098 | SCH-211803 | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL215180 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL326450 | — | Ki | = | 11220.0 | nM | 4.95 |