Assay Detail
Binding
CHEMBL2317650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.66 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.55 |
| CHEMBL2312396 | — | — | 1 | 5.09 |
| CHEMBL2312403 | — | — | 1 | 4.39 |
| CHEMBL2312398 | — | — | 1 | 4.31 |
| CHEMBL2312680 | — | — | 1 | 4.27 |
| CHEMBL2312683 | — | — | 1 | 4.25 |
| CHEMBL2312397 | — | — | 1 | 4.25 |
| CHEMBL2312400 | — | — | 1 | 4.15 |
| CHEMBL2312402 | — | — | 1 | - |
| CHEMBL2312401 | — | — | 1 | - |
| CHEMBL2312399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL2312396 | — | Ki | = | 8050.0 | nM | 5.09 |
| CHEMBL2312403 | — | Ki | = | 40800.0 | nM | 4.39 |
| CHEMBL2312398 | — | Ki | = | 49200.0 | nM | 4.31 |
| CHEMBL2312680 | — | Ki | = | 53300.0 | nM | 4.27 |
| CHEMBL2312683 | — | Ki | = | 56500.0 | nM | 4.25 |
| CHEMBL2312397 | — | Ki | = | 56200.0 | nM | 4.25 |
| CHEMBL2312400 | — | Ki | = | 71100.0 | nM | 4.15 |
| CHEMBL2312402 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2312401 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2312399 | — | Ki | > | 100000.0 | nM | - |