Assay Detail
Binding
CHEMBL2317823
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Inhibition of SERT (unknown origin) assessed as serotonin reuptake
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Organosilicon molecules with medicinal applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.39 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252720 | (S)-VENLAFAXINE | — | 1 | 7.70 |
| CHEMBL2204341 | — | — | 1 | 5.97 |
| CHEMBL427215 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252720 | (S)-VENLAFAXINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2204341 | — | IC50 | = | 1063.0 | nM | 5.97 |
| CHEMBL427215 | — | IC50 | = | 3168.0 | nM | 5.50 |