Assay Detail
Functional
CHEMBL2321082
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Cytotoxicity against human T47D cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.32 | 4.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316052 | — | — | 1 | 4.65 |
| CHEMBL2311587 | — | — | 1 | 4.47 |
| CHEMBL2316050 | — | — | 1 | 4.37 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.29 |
| CHEMBL2316042 | — | — | 1 | 4.26 |
| CHEMBL2316315 | — | — | 1 | 4.21 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 4.19 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | 4.15 |
| CHEMBL2316047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316052 | — | IC50 | = | 22520.0 | nM | 4.65 |
| CHEMBL2311587 | — | IC50 | = | 34090.0 | nM | 4.47 |
| CHEMBL2316050 | — | IC50 | = | 42950.0 | nM | 4.37 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 51800.0 | nM | 4.29 |
| CHEMBL2316042 | — | IC50 | = | 55380.0 | nM | 4.26 |
| CHEMBL2316315 | — | IC50 | = | 62410.0 | nM | 4.21 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 65130.0 | nM | 4.19 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 70100.0 | nM | 4.15 |
| CHEMBL2316047 | — | IC50 | = | 184130.0 | nM | - |