Assay Detail
Functional
CHEMBL2327112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine incorporation assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.23 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151383 | — | — | 1 | 8.66 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.55 |
| CHEMBL2322218 | — | — | 1 | 8.03 |
| CHEMBL2322220 | — | — | 1 | 7.92 |
| CHEMBL2322213 | — | — | 1 | 7.67 |
| CHEMBL2322221 | — | — | 1 | 7.66 |
| CHEMBL2058009 | — | — | 1 | 7.53 |
| CHEMBL2322224 | — | — | 1 | 7.52 |
| CHEMBL2322510 | — | — | 1 | 7.41 |
| CHEMBL2322223 | — | — | 1 | 7.31 |
| CHEMBL2322216 | — | — | 1 | 6.95 |
| CHEMBL2322212 | — | — | 1 | 6.95 |
| CHEMBL2322505 | — | — | 1 | 6.91 |
| CHEMBL2322509 | — | — | 1 | 6.84 |
| CHEMBL2322508 | — | — | 1 | 6.84 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.68 |
| CHEMBL2322222 | — | — | 1 | 6.50 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.77 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | — | 1 | 5.70 |
| CHEMBL2322214 | — | — | 1 | - |
| CHEMBL2322215 | — | — | 1 | - |
| CHEMBL2058024 | — | — | 1 | - |
| CHEMBL2322507 | — | — | 1 | - |
| CHEMBL2322506 | — | — | 1 | - |
| CHEMBL2058015 | — | — | 1 | - |
| CHEMBL2058020 | — | — | 1 | - |
| CHEMBL2322217 | — | — | 1 | - |
| CHEMBL2322219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151383 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2322218 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2322220 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL2322213 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL2322221 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL2058009 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL2322224 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL2322510 | — | IC50 | = | 38.8 | nM | 7.41 |
| CHEMBL2322223 | — | IC50 | = | 48.8 | nM | 7.31 |
| CHEMBL2322216 | — | IC50 | = | 111.5 | nM | 6.95 |
| CHEMBL2322212 | — | IC50 | = | 112.3 | nM | 6.95 |
| CHEMBL2322505 | — | IC50 | = | 123.7 | nM | 6.91 |
| CHEMBL2322509 | — | IC50 | = | 143.2 | nM | 6.84 |
| CHEMBL2322508 | — | IC50 | = | 143.7 | nM | 6.84 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 209.5 | nM | 6.68 |
| CHEMBL2322222 | — | IC50 | = | 312.6 | nM | 6.50 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 1696.0 | nM | 5.77 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | IC50 | = | 1998.0 | nM | 5.70 |
| CHEMBL2322214 | — | IC50 | - | — | - | |
| CHEMBL2322215 | — | IC50 | - | — | - | |
| CHEMBL2058024 | — | IC50 | - | — | - | |
| CHEMBL2322507 | — | IC50 | - | — | - | |
| CHEMBL2322506 | — | IC50 | - | — | - | |
| CHEMBL2058015 | — | IC50 | - | — | - | |
| CHEMBL2058020 | — | IC50 | - | — | - | |
| CHEMBL2322217 | — | IC50 | - | — | - | |
| CHEMBL2322219 | — | IC50 | - | — | - |