Compound Detail
CHEMBL2151383
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Basic Information
| ChEMBL ID | CHEMBL2151383 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IFUMEMTWYQZICJ-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
453.6
MW (Da)
5.46
ALogP
5
HBA
3
HBD
80.2
PSA (Ų)
0.29
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 8.66 | 8.51 | 2.2 | 2 |
| L6 CHEMBL614793 | IC50 | 5.57 | 5.565 | 2700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 2.2 | nM | 8.66 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 aft... | 23360309 |
| Plasmodium falciparum | IC50 | = | 4.4 | nM | 8.36 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 a... | 23360309 |
| L6 | IC50 | = | 2700.0 | nM | 5.57 | Cytotoxicity against rat L6 cells | 23151321 |
| L6 | IC50 | = | 2734.0 | nM | 5.56 | Toxicity against rat L6 cells after 72 hrs by Alamar blue assay | 23360309 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23360309 | 10.1021/jm300887b | Plasmodium falciparum | 3 |
| 23360309 | 10.1021/jm300887b | Unchecked | 2 |
| 23151321 | 10.1016/j.ejmech.2012.10.023 | L6 | 1 |
| 23360309 | 10.1021/jm300887b | L6 | 1 |
Data from ChEMBL 36 via Core Engine