Assay Detail
Toxicity
CHEMBL2327115
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Toxicity against rat L6 cells after 72 hrs by Alamar blue assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.08 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.84 |
| CHEMBL2322214 | — | — | 1 | 7.74 |
| CHEMBL2322505 | — | — | 1 | 7.19 |
| CHEMBL2322504 | — | — | 1 | 6.68 |
| CHEMBL2058020 | — | — | 1 | 6.59 |
| CHEMBL2058015 | — | — | 1 | 6.57 |
| CHEMBL2058009 | — | — | 1 | 6.55 |
| CHEMBL2322506 | — | — | 1 | 6.47 |
| CHEMBL2058024 | — | — | 1 | 6.42 |
| CHEMBL2322219 | — | — | 1 | 6.40 |
| CHEMBL2322503 | — | — | 1 | 6.16 |
| CHEMBL2322507 | — | — | 1 | 6.03 |
| CHEMBL2322213 | — | — | 1 | 5.96 |
| CHEMBL2322216 | — | — | 1 | 5.91 |
| CHEMBL2322218 | — | — | 1 | 5.91 |
| CHEMBL2322223 | — | — | 1 | 5.89 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | — | 1 | 5.84 |
| CHEMBL2322217 | — | — | 1 | 5.76 |
| CHEMBL2322212 | — | — | 1 | 5.56 |
| CHEMBL2151383 | — | — | 1 | 5.56 |
| CHEMBL2322224 | — | — | 1 | 5.56 |
| CHEMBL2322220 | — | — | 1 | 5.55 |
| CHEMBL2322221 | — | — | 1 | 5.51 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.50 |
| CHEMBL2322510 | — | — | 1 | 5.47 |
| CHEMBL2322508 | — | — | 1 | 5.46 |
| CHEMBL2322509 | — | — | 1 | 5.45 |
| CHEMBL2322222 | — | — | 1 | 5.45 |
| CHEMBL2322215 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL2322214 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL2322505 | — | IC50 | = | 65.2 | nM | 7.19 |
| CHEMBL2322504 | — | IC50 | = | 208.9 | nM | 6.68 |
| CHEMBL2058020 | — | IC50 | = | 258.3 | nM | 6.59 |
| CHEMBL2058015 | — | IC50 | = | 268.6 | nM | 6.57 |
| CHEMBL2058009 | — | IC50 | = | 279.2 | nM | 6.55 |
| CHEMBL2322506 | — | IC50 | = | 338.1 | nM | 6.47 |
| CHEMBL2058024 | — | IC50 | = | 382.8 | nM | 6.42 |
| CHEMBL2322219 | — | IC50 | = | 397.3 | nM | 6.40 |
| CHEMBL2322503 | — | IC50 | = | 692.7 | nM | 6.16 |
| CHEMBL2322507 | — | IC50 | = | 923.8 | nM | 6.03 |
| CHEMBL2322213 | — | IC50 | = | 1099.0 | nM | 5.96 |
| CHEMBL2322216 | — | IC50 | = | 1228.0 | nM | 5.91 |
| CHEMBL2322218 | — | IC50 | = | 1244.0 | nM | 5.91 |
| CHEMBL2322223 | — | IC50 | = | 1282.0 | nM | 5.89 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | IC50 | = | 1459.0 | nM | 5.84 |
| CHEMBL2322217 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL2322212 | — | IC50 | = | 2728.0 | nM | 5.56 |
| CHEMBL2151383 | — | IC50 | = | 2734.0 | nM | 5.56 |
| CHEMBL2322224 | — | IC50 | = | 2732.0 | nM | 5.56 |
| CHEMBL2322220 | — | IC50 | = | 2826.0 | nM | 5.55 |
| CHEMBL2322221 | — | IC50 | = | 3079.0 | nM | 5.51 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 3194.0 | nM | 5.50 |
| CHEMBL2322510 | — | IC50 | = | 3359.0 | nM | 5.47 |
| CHEMBL2322508 | — | IC50 | = | 3473.0 | nM | 5.46 |
| CHEMBL2322509 | — | IC50 | = | 3551.0 | nM | 5.45 |
| CHEMBL2322222 | — | IC50 | = | 3556.0 | nM | 5.45 |
| CHEMBL2322215 | — | IC50 | = | 4463.0 | nM | 5.35 |