Compound Detail
CHEMBL2322217
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2322217 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PGZMRQMIYQXFHW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
403.5
MW (Da)
4.73
ALogP
4
HBA
3
HBD
71.0
PSA (Ų)
0.37
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.98 | 6.98 | 104.1 | 1 |
| L6 CHEMBL614793 | IC50 | 5.76 | 5.76 | 1740.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 104.1 | nM | 6.98 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 a... | 23360309 |
| L6 | IC50 | = | 1740.0 | nM | 5.76 | Toxicity against rat L6 cells after 72 hrs by Alamar blue assay | 23360309 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23360309 | 10.1021/jm300887b | Plasmodium falciparum | 2 |
| 23360309 | 10.1021/jm300887b | Unchecked | 1 |
| 23360309 | 10.1021/jm300887b | L6 | 1 |
Data from ChEMBL 36 via Core Engine