Assay Detail
Functional
CHEMBL2327114
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 72 hrs by [3H]hypoxanthine incorporation assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.57 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322224 | — | — | 1 | 8.68 |
| CHEMBL2322221 | — | — | 1 | 8.66 |
| CHEMBL2322220 | — | — | 1 | 8.40 |
| CHEMBL2322223 | — | — | 1 | 8.39 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.37 |
| CHEMBL2151383 | — | — | 1 | 8.36 |
| CHEMBL2322216 | — | — | 1 | 8.04 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.03 |
| CHEMBL2058020 | — | — | 1 | 7.98 |
| CHEMBL2322507 | — | — | 1 | 7.97 |
| CHEMBL2322504 | — | — | 1 | 7.94 |
| CHEMBL2058015 | — | — | 1 | 7.93 |
| CHEMBL2322214 | — | — | 1 | 7.85 |
| CHEMBL2322218 | — | — | 1 | 7.67 |
| CHEMBL2322222 | — | — | 1 | 7.60 |
| CHEMBL2322219 | — | — | 1 | 7.59 |
| CHEMBL2322213 | — | — | 1 | 7.58 |
| CHEMBL2322212 | — | — | 1 | 7.42 |
| CHEMBL2322506 | — | — | 1 | 7.30 |
| CHEMBL2322510 | — | — | 1 | 7.28 |
| CHEMBL2322509 | — | — | 1 | 7.26 |
| CHEMBL2322505 | — | — | 1 | 7.20 |
| CHEMBL2322508 | — | — | 1 | 7.19 |
| CHEMBL2058024 | — | — | 1 | 7.13 |
| CHEMBL2058009 | — | — | 1 | 7.10 |
| CHEMBL2322503 | — | — | 1 | 7.01 |
| CHEMBL2322217 | — | — | 1 | 6.98 |
| CHEMBL2322215 | — | — | 1 | 6.59 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.80 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322224 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2322221 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2322220 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2322223 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL2151383 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2322216 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2058020 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL2322507 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL2322504 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2058015 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL2322214 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL2322218 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL2322222 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL2322219 | — | IC50 | = | 25.8 | nM | 7.59 |
| CHEMBL2322213 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL2322212 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL2322506 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL2322510 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL2322509 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL2322505 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2322508 | — | IC50 | = | 63.9 | nM | 7.19 |
| CHEMBL2058024 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL2058009 | — | IC50 | = | 78.8 | nM | 7.10 |
| CHEMBL2322503 | — | IC50 | = | 98.1 | nM | 7.01 |
| CHEMBL2322217 | — | IC50 | = | 104.1 | nM | 6.98 |
| CHEMBL2322215 | — | IC50 | = | 258.1 | nM | 6.59 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL484522 | 11-CHLORONEOCRYPTOLEPINE | IC50 | = | 2055.0 | nM | 5.69 |