Assay Detail
Binding
CHEMBL2328308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of Aβ plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.34 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78012 | — | — | 1 | 8.10 |
| CHEMBL2326891 | — | — | 1 | 7.86 |
| CHEMBL2326889 | — | — | 1 | 7.54 |
| CHEMBL2326888 | — | — | 1 | 7.41 |
| CHEMBL2326890 | — | — | 1 | 7.08 |
| CHEMBL2326892 | — | — | 1 | 6.92 |
| CHEMBL2326893 | — | — | 1 | 6.45 |
| CHEMBL2326887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78012 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2326891 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL2326889 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL2326888 | — | Ki | = | 39.2 | nM | 7.41 |
| CHEMBL2326890 | — | Ki | = | 83.5 | nM | 7.08 |
| CHEMBL2326892 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL2326893 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL2326887 | — | Ki | > | 10000.0 | nM | - |