Assay Detail
Binding
CHEMBL2328973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hr
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cell division cycle 7-related protein kinase (CHEMBL5443) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.31 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1958408 | — | — | 1 | 9.55 |
| CHEMBL2322677 | — | — | 1 | 9.05 |
| CHEMBL2322674 | — | — | 1 | 8.85 |
| CHEMBL2322683 | — | — | 1 | 8.77 |
| CHEMBL2322682 | — | — | 1 | 8.49 |
| CHEMBL2322684 | — | — | 1 | 8.47 |
| CHEMBL2322675 | — | — | 1 | 8.26 |
| CHEMBL2322673 | — | — | 1 | 8.11 |
| CHEMBL2322678 | — | — | 1 | 8.06 |
| CHEMBL2322679 | — | — | 1 | 7.89 |
| CHEMBL2322680 | — | — | 1 | 7.82 |
| CHEMBL2322681 | — | — | 1 | 7.57 |
| CHEMBL2322676 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1958408 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL2322677 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2322674 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2322683 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2322682 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2322684 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL2322675 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL2322673 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL2322678 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL2322679 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2322680 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2322681 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2322676 | — | Ki | = | 67.0 | nM | 7.17 |