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Assay Detail

CHEMBL2329367

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Binding
Inhibition of Toxoplasma gondii farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Toxoplasma gondii
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Farnesyl diphosphate synthase (CHEMBL5831)
Type SINGLE PROTEIN
Organism Toxoplasma gondii

Publication

Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.
Recher M, Barboza AP, Li ZH, Galizzi M, Ferrer-Casal M, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.
Eur J Med Chem (2013) 60 : 431 -440
PubMed 23318904 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.28 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2326236 1 8.05
CHEMBL2326222 1 7.89
CHEMBL2326237 1 7.80
CHEMBL2326232 1 7.68
CHEMBL2326230 1 7.62
CHEMBL2326231 1 7.60
CHEMBL2326226 1 7.32
CHEMBL2326238 1 7.25
CHEMBL2096957 1 7.18
CHEMBL2326229 1 7.16
CHEMBL923 RISEDRONIC ACID 4.0 1 7.13
CHEMBL2326227 1 6.96
CHEMBL2326228 1 6.51
CHEMBL2326225 1 5.74
CHEMBL2326234 1 -
CHEMBL2326235 1 -
CHEMBL110 BENZNIDAZOLE 4.0 1 -
CHEMBL2326224 1 -
CHEMBL2326223 1 -
CHEMBL2326233 1 -
CHEMBL2326220 1 -
CHEMBL2326221 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2326236 IC50 = 9.0 nM 8.05
CHEMBL2326222 IC50 = 13.0 nM 7.89
CHEMBL2326237 IC50 = 16.0 nM 7.80
CHEMBL2326232 IC50 = 21.0 nM 7.68
CHEMBL2326230 IC50 = 24.0 nM 7.62
CHEMBL2326231 IC50 = 25.0 nM 7.60
CHEMBL2326226 IC50 = 48.0 nM 7.32
CHEMBL2326238 IC50 = 56.0 nM 7.25
CHEMBL2096957 IC50 = 66.0 nM 7.18
CHEMBL2326229 IC50 = 69.0 nM 7.16
CHEMBL923 RISEDRONIC ACID IC50 = 74.0 nM 7.13
CHEMBL2326227 IC50 = 110.0 nM 6.96
CHEMBL2326228 IC50 = 307.0 nM 6.51
CHEMBL2326225 IC50 = 1834.0 nM 5.74
CHEMBL2326234 IC50 > 10000.0 nM -
CHEMBL2326235 IC50 > 10000.0 nM -
CHEMBL110 BENZNIDAZOLE IC50 - -
CHEMBL2326224 IC50 > 1000.0 nM -
CHEMBL2326223 IC50 < 1000.0 nM -
CHEMBL2326233 IC50 > 10000.0 nM -
CHEMBL2326220 IC50 > 10000.0 nM -
CHEMBL2326221 IC50 > 10000.0 nM -