Assay Detail
Functional
CHEMBL2329462
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Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometric analysis relative to control
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-4A5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.39 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323768 | KOENIMBINE | — | 1 | 5.92 |
| CHEMBL495873 | MAHANIMBINE | — | 1 | 5.85 |
| CHEMBL2323762 | — | — | 1 | 5.66 |
| CHEMBL2323767 | — | — | 1 | 5.54 |
| CHEMBL2323763 | — | — | 1 | 5.42 |
| CHEMBL2323766 | EUCHRESTINE B | — | 1 | 5.39 |
| CHEMBL2323765 | EUSTIFOLINE C | — | 1 | 5.08 |
| CHEMBL46723 | — | — | 1 | 4.87 |
| CHEMBL2323764 | — | — | 1 | 4.80 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL243580 | CARBAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323768 | KOENIMBINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL495873 | MAHANIMBINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2323762 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2323767 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2323763 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2323766 | EUCHRESTINE B | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2323765 | EUSTIFOLINE C | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL46723 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL2323764 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 174000.0 | nM | - |
| CHEMBL243580 | CARBAZOLE | IC50 | > | 100000.0 | nM | - |