Compound Detail
CHEMBL495873
MAHANIMBINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL495873 |
| Name | MAHANIMBINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HTNVFUBCWIYPJN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
331.5
MW (Da)
6.54
ALogP
1
HBA
1
HBD
25.0
PSA (Ų)
0.54
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Pancreatic triacylglycerol lipase CHEMBL1812 | IC50 | 4.75 | 4.75 | 17900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells after 72... | 23376010 |
| Pancreatic triacylglycerol lipase | IC50 | = | 17900.0 | nM | 4.75 | Inhibition of pancreatic lipase (unknown origin) | 27908755 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23376010 | 10.1016/j.bmc.2013.01.012 | Tyrosinase | 5 |
| 23376010 | 10.1016/j.bmc.2013.01.012 | ADMET | 4 |
| 23376010 | 10.1016/j.bmc.2013.01.012 | Unchecked | 3 |
| 10757740 | 10.1021/np990570g | Human immunodeficiency virus | 1 |
| 27908755 | 10.1016/j.bmc.2016.11.031 | Pancreatic triacylglycerol lipase | 1 |
Data from ChEMBL 36 via Core Engine