Assay Detail
Functional
CHEMBL2329607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of c-MET phosphorylation at tyrosine Y1349 in human GTL16 cells xenografted in po dosed mouse after 1 hr by Western blotting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | GTL16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.89 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323775 | MK-8033 | 1.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323775 | MK-8033 | IC50 | = | 1300.0 | nM | 5.89 |