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Assay Detail

CHEMBL2329763

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-leukemic activity of ubiquinone-based compounds targeting trans-plasma membrane electron transport.
Grasso C, Larsen L, McConnell M, Smith RA, Berridge MV.
J Med Chem (2013) 56 : 3168 -3176
PubMed 23432053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.16 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2323213 1 6.00
CHEMBL2323216 1 5.70
CHEMBL2323214 1 5.70
CHEMBL2323215 1 5.52
CHEMBL2323210 1 5.52
CHEMBL2323209 1 5.52
CHEMBL2323204 1 4.89
CHEMBL2323217 1 4.89
CHEMBL2323207 1 4.80
CHEMBL2323211 1 4.48
CHEMBL2323212 1 4.46
CHEMBL252556 IDEBENONE 4.0 1 4.44
CHEMBL2323208 1 -
CHEMBL2323206 1 -
CHEMBL2323205 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2323213 IC50 = 1000.0 nM 6.00
CHEMBL2323216 IC50 = 2000.0 nM 5.70
CHEMBL2323214 IC50 = 2000.0 nM 5.70
CHEMBL2323215 IC50 = 3000.0 nM 5.52
CHEMBL2323210 IC50 = 3000.0 nM 5.52
CHEMBL2323209 IC50 = 3000.0 nM 5.52
CHEMBL2323204 IC50 = 13000.0 nM 4.89
CHEMBL2323217 IC50 = 13000.0 nM 4.89
CHEMBL2323207 IC50 = 16000.0 nM 4.80
CHEMBL2323211 IC50 = 33000.0 nM 4.48
CHEMBL2323212 IC50 = 35000.0 nM 4.46
CHEMBL252556 IDEBENONE IC50 = 36000.0 nM 4.44
CHEMBL2323208 IC50 > 200000.0 nM -
CHEMBL2323206 IC50 = 143000.0 nM -
CHEMBL2323205 IC50 > 200000.0 nM -