Assay Detail
Functional
CHEMBL2339171
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Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction treated after KCl-challenge
11
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.81 | 6.90 |
| pIC50 | 4 | - | - |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | 6.90 |
| CHEMBL2337401 | — | — | 2 | 5.32 |
| CHEMBL2337400 | — | — | 2 | 5.22 |
| CHEMBL2337404 | — | — | 2 | - |
| CHEMBL2337403 | — | — | 2 | - |
| CHEMBL2337402 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL730 | NITROGLYCERIN | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL2337401 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL2337400 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL2337404 | — | pIC50 | - | — | - | |
| CHEMBL2337403 | — | pIC50 | - | — | - | |
| CHEMBL2337402 | — | pIC50 | - | — | - | |
| CHEMBL2337401 | — | pIC50 | - | — | - | |
| CHEMBL2337400 | — | Activity | - | — | - | |
| CHEMBL2337404 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2337403 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2337402 | — | IC50 | >= | 10000.0 | nM | - |