Assay Detail
Binding
CHEMBL2339175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of arachidonic acid-induced COX1 activity in mouse J774 cells assessed as decrease in PGE2 levels incubated for 15 mins prior to arachidonic acid-challenge measured after 30 mins by RIA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.49 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337405 | — | — | 1 | 5.54 |
| CHEMBL2337398 | — | — | 1 | 5.43 |
| CHEMBL2337399 | — | — | 1 | - |
| CHEMBL2337397 | — | — | 1 | - |
| CHEMBL2337396 | — | — | 1 | - |
| CHEMBL2337409 | — | — | 1 | - |
| CHEMBL2337408 | — | — | 1 | - |
| CHEMBL2337407 | — | — | 1 | - |
| CHEMBL2337406 | — | — | 1 | - |
| CHEMBL2337404 | — | — | 1 | - |
| CHEMBL2337403 | — | — | 1 | - |
| CHEMBL2337402 | — | — | 1 | - |
| CHEMBL2337401 | — | — | 1 | - |
| CHEMBL2337400 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337405 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2337398 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2337399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337397 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337409 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337408 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337407 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337404 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337403 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337402 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337401 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337400 | — | IC50 | > | 10000.0 | nM | - |