Assay Detail
Functional
CHEMBL2340715
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Antiparasitic activity against Trypanosoma brucei assessed as growth inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.40 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.52 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.85 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL265502 | SURAMIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL830 | EFLORNITHINE | IC50 | = | 59000.0 | nM | 4.23 |