Assay Detail
Binding
CHEMBL2340955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.49 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333326 | — | — | 1 | 9.30 |
| CHEMBL2333334 | — | — | 1 | 8.26 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 8.20 |
| CHEMBL78322 | — | — | 1 | 8.17 |
| CHEMBL2333333 | — | — | 1 | 7.88 |
| CHEMBL442373 | — | — | 1 | 7.87 |
| CHEMBL2333327 | — | — | 1 | 7.72 |
| CHEMBL307160 | — | — | 1 | 7.65 |
| CHEMBL2333332 | — | — | 1 | 7.61 |
| CHEMBL2333330 | — | — | 1 | 7.59 |
| CHEMBL2333329 | — | — | 1 | 7.10 |
| CHEMBL2333331 | — | — | 1 | 7.03 |
| CHEMBL1083652 | — | — | 1 | 7.00 |
| CHEMBL2333328 | — | — | 1 | 6.81 |
| CHEMBL2333335 | — | — | 1 | 6.57 |
| CHEMBL2333336 | — | — | 1 | 6.38 |
| CHEMBL2333337 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333326 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2333334 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL78322 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2333333 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL442373 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL2333327 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL307160 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL2333332 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL2333330 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL2333329 | — | IC50 | = | 80.1 | nM | 7.10 |
| CHEMBL2333331 | — | IC50 | = | 92.5 | nM | 7.03 |
| CHEMBL1083652 | — | IC50 | = | 99.1 | nM | 7.00 |
| CHEMBL2333328 | — | IC50 | = | 156.3 | nM | 6.81 |
| CHEMBL2333335 | — | IC50 | = | 268.4 | nM | 6.57 |
| CHEMBL2333336 | — | IC50 | = | 415.8 | nM | 6.38 |
| CHEMBL2333337 | — | IC50 | = | 785.3 | nM | 6.11 |