Assay Detail
Binding
CHEMBL2341302
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Inhibition of human carbonic anhydrase 5A preincubated for 15 mins by CO2 hydration stopped-flow assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.15 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323139 | — | — | 1 | 5.47 |
| CHEMBL550572 | — | — | 1 | 5.36 |
| CHEMBL2323138 | — | — | 1 | 5.13 |
| CHEMBL2323140 | — | — | 1 | 5.10 |
| CHEMBL2323135 | — | — | 1 | 5.08 |
| CHEMBL2323137 | — | — | 1 | 5.03 |
| CHEMBL2323136 | — | — | 1 | 5.02 |
| CHEMBL2323134 | — | — | 1 | 5.01 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323139 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL550572 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL2323138 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL2323140 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL2323135 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL2323137 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL2323136 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL2323134 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL14060 | PHENOL | Ki | = | 218000.0 | nM | - |