Assay Detail
ADMET
CHEMBL2344726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.73 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336418 | — | — | 1 | 5.46 |
| CHEMBL2336422 | — | — | 1 | 4.89 |
| CHEMBL2336412 | — | — | 1 | 4.75 |
| CHEMBL2336424 | — | — | 1 | 4.62 |
| CHEMBL2336421 | — | — | 1 | 4.60 |
| CHEMBL450668 | — | — | 1 | 4.58 |
| CHEMBL2336415 | — | — | 1 | 4.50 |
| CHEMBL454791 | — | — | 1 | 4.44 |
| CHEMBL2336411 | — | — | 1 | - |
| CHEMBL2336413 | — | — | 1 | - |
| CHEMBL2336416 | — | — | 1 | - |
| CHEMBL2336417 | — | — | 1 | - |
| CHEMBL2336419 | — | — | 1 | - |
| CHEMBL454751 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336418 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2336422 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2336412 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2336424 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2336421 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL450668 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL2336415 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL454791 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2336411 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2336413 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2336416 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2336417 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2336419 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL454751 | — | IC50 | > | 40000.0 | nM | - |